Evaluation of Clinical, Demographic, Pathological, and Molecular Factors with Survival Rate of Patients with Oral Squamous cell Carcinoma in Yazd city During 1998–2008

Introdouction: Squamous cell carcinoma is the most common oral cancer and the prognosis because of a late diagnosis remains poor despite numerous treatments. Therefore, we conducted a cross-sectional study to investigate the relationships between survival rate(SR) of oral squamous cell carcinoma (OSCC) and clinical,demographic, pathological, and molecular factors in Yazd city during 1998&ndash; 2008. Materials and methods: Data related to 30 Yazdian patients with OSCC who were referred to Shahid Sadoughi Dental School and Hospital during 1998&ndash;2008 were evaluated according to census data. Clinical and histopathological data were gathered via phone calls, and archived specimens were immunohistochemically stained to examine the cell proliferation index (Ki-67), the anti-apoptotic index (bcl2), and a tumor suppressor indicator(p53). The data were analyzed using SPSS statistical software (V.17) via a Kaplan&ndash;Meier analysis, and p <0.05 was considered significant. Results: Eighteen cases (60%) were females and 12(40%) were males. The mean 5-year SR was lower in men than women and in patients >50 years of age than <50 years, the mean SR from lowest to highest were record to labial, lingual and intraoral involvement respectively and for smokers and patients with a moderate disease grade(II) and intense p53 staining tended to be lower than other categories however, the differences were not significant. The overall 5-year SR of patients was 55% in this study, and the mean survival was 6.6 years. Conclusion: The SR was lower in older men and smokers Therefore, a more radical treatment and longer follow-upafter treatment for older male smokers are recommended.